The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) is a 1,3-dipolar cycloaddition between an azide and a terminal or internal alkyne to give a 1,2,3-triazole. CuAAC reaction is versatile in numerous applications due to its “click reaction” features such as simplicity, fast reaction rate with high yields, orthogonal reactivity and tolerance of various solvents. Our interest is to develop a new strategy to spatially and temperately control CuAAC reaction in three demensions. The anchor groups (azide or alkyne) were firstly immobilized preciously via multiphoton grafting. The levels of immobilization can be spatially and temperately controlled by simply altering the irradiation exposure time or laser intensity during the photografting process. Then the anchor groups reacted with corresponding functionalities via CuAAC reaction to obtained desired functions. [1,2]

[1] A. Ovsianikov, Z. Li, J. Torgersen, J. Stampfl, R. Liska: "Selective Functionalization of 3D Matrices Via Multiphoton Grafting and Subsequent Click Chemsitry"; Advanced Functional Materials, 22 (2012), 16; S. 3429 - 3433.

[2] A. Ovsianikov, Z. Li, A. Ajami, J. Torgersen, W. Husinsky, J. Stampfl, R. Liska: "3D grafting via three-photon induced photolysis of aromatic azides"; Applied Physics A: Materials Science & Processing, 108 (2012), 1; S. 29 - 34.