Publications

Full publication list: https://orcid.org/0000-0002-5482-6225

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2023

  • Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR.

Kuschert, S., Stroet, M., Chin, Y. K.-Y., Conibear, A. C., Jia, X., Lee, T., Bartling, C. R. O., Strømgaard, K., Güntert, P., Rosengren, K. J., Mark, A. E., & Mobli, M.

Magn. Reson. 2023, 4, 57-72. DOI: 10.5194/mr-4-57-2023.

2021

  • Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications.

Niederacher, G.; Urwin, D.; Dijkwel, Y.; Tremethick, D. J.; Rosengren, K. J.; Becker, C. F. W.; Conibear, A. C.

RSC Chem. Biol. 2021, 2, 537-550. DOI: 10.1039/d0cb00175a.

 

  • Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding.

Ho, T. N. T.; Lee, H. S.; Swaminathan, S.; Goodwin, L.; Rai, N.; Ushay, B.; Lewis, R. J.; Rosengren, K. J.; Conibear, A. C.

RSC Med. Chem. 2021, 12 (9), 1574-1584. DOI: 10.1039/d1md00182e.

 

  • Segmental and site-specific isotope labelling strategies for structural analysis of posttranslationally modified proteins.

Vogl, D. P.; Conibear, A. C.; Becker, C. F. W.

RSC Chem. Biol. 2021, 2 (5), 1441-1461. DOI: 10.1039/d1cb00045d.

 

  • A conserved β‐bulge glycine residue facilitates folding and increases stability of the mouse α‐defensin cryptdin‐4.

Clark, R. J.; Phan, T. H.; Song, A.; Ouellette, A. J.; Conibear, A. C.; Rosengren, K. J.

Peptide Science 2021, 114 (1), e24250. DOI: 10.1002/pep2.24250.

 

2020

  • Deciphering protein post-translational modifications using chemical biology tools.

Conibear, A. C.

Nat. Rev. Chem. 2020, 4 (12), 674-695. DOI: 10.1038/s41570-020-00223-8.

 

  • Recent Advances in Peptide-Based Approaches for Cancer Treatment.

Conibear, A. C.; Schmid, A.; Kamalov, M.; Becker, C. F. W.; Bello, C.

Curr. Med. Chem. 2020, 27 (8), 1174-1205. DOI: 10.2174/0929867325666171123204851.

 

  • Synthesis and anti-parasitic activity of achiral N-benzylated phosphoramidic acid derivatives.

Adeyemi, C. M.; Conibear, A. C.; Mutorwa, M. K.; Nokalipa, I. C.; Isaacs, M.; Mnkandhla, D.; Hoppe, H. C.; Lobb, K. A.; Klein, R.; Kaye, P. T.

Bioorg. Chem. 2020, 101, 103947. DOI: 10.1016/j.bioorg.2020.103947.

 

2019

  • Random coil shifts of posttranslationally modified amino acids.

Conibear, A. C.; Rosengren, K. J.; Becker, C. F. W.; Kaehlig, H. J.

Biomol. NMR 2019, 73 (10-11), 587-599. DOI: 10.1007/s10858-019-00270-4.

 

  • Multifunctional Scaffolds for Assembling Cancer-Targeting Immune Stimulators Using Chemoselective Ligations.

Conibear, A. C.; Thewes, K.; Groysbeck, N.; Becker, C. F. W.

Front. Chem. 2019, 7, 113. DOI: 10.3389/fchem.2019.00113.

 

  • Tumor-Targeting Immune System Engagers (ISErs) Activate Human Neutrophils after Binding to Cancer Cells.

Potgens, A. J. G.; Conibear, A. C.; Altdorf, C.; Hilzendeger, C.; Becker, C. F. W.

Biochemistry 2019, 58 (22), 2642-2652. DOI: 10.1021/acs.biochem.9b00169.

 

  • Protein Chemistry Looking Ahead: 8(th) Chemical Protein Synthesis Meeting 16-19 June 2019, Berlin, Germany.

Bello, C.; Hartrampf, N.; Walport, L. J.; Conibear, A. C.

Cell Chem. Biol. 2019, 26 (10), 1349-1354. DOI: 10.1016/j.chembiol.2019.09.011.

 

2018

  • Synthetic Cancer-Targeting Innate Immune Stimulators Give Insights into Avidity Effects.

Conibear, A. C.; Potgens, A. J. G.; Thewes, K.; Altdorf, C.; Hilzendeger, C.; Becker, C. F. W.

ChemBioChem 2018, 19 (5), 459-469. DOI: 10.1002/cbic.201700522.

 

  • Native chemical ligation in protein synthesis and semi-synthesis.

Conibear, A. C.; Watson, E. E.; Payne, R. J.; Becker, C. F. W.

Chem. Soc. Rev. 2018, 47 (24), 9046-9068. DOI: 10.1039/c8cs00573g.

 

  • Advancing the Frontiers of Chemical Protein Synthesis-The 7(th) CPS Meeting, Haifa, Israel.

Conibear, A. C.; Muttenthaler, M.

Cell Chem. Biol. 2018, 25 (3), 247-254. DOI: 10.1016/j.chembiol.2018.03.001.

 

2017

  • Multifunctional alphavbeta6 Integrin-Specific Peptide-Pt(IV) Conjugates for Cancer Cell Targeting.

Conibear, A. C.; Hager, S.; Mayr, J.; Klose, M. H. M.; Keppler, B. K.; Kowol, C. R.; Heffeter, P.; Becker, C. F. W.

Bioconjug. Chem. 2017, 28 (9), 2429-2439. DOI: 10.1021/acs.bioconjchem.7b00421.

 

  • A comparative study of synthetic and semisynthetic approaches for ligating the epidermal growth factor to a bivalent scaffold.

Gell, A. L.; Groysbeck, N.; Becker, C. F. W.; Conibear, A. C.

J. Pept. Sci. 2017, 23 (12), 871-879. DOI: 10.1002/psc.3051.

 

  • Synthetic integrin-binding immune stimulators target cancer cells and prevent tumor formation.

Brehs, M.; Potgens, A. J. G.; Steitz, J.; Thewes, K.; Schwarz, J.; Conibear, A. C.; Bartneck, M.; Tacke, F.; Becker, C. F. W.

Sci. Rep. 2017, 7 (1), 17592. DOI: 10.1038/s41598-017-17627-0.

 

2016 and earlier

  • Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization.

Conibear, A. C.; Chaousis, S.; Durek, T.; Rosengren, K. J.; Craik, D. J.; Schroeder, C. I.

Biopolymers 2016, 106 (1), 89-100. DOI: 10.1002/bip.22767.

 

  • Mirror Images of Antimicrobial Peptides Provide Reflections on Their Functions and Amyloidogenic Properties.

Wang, C. K.; King, G. J.; Conibear, A. C.; Ramos, M. C.; Chaousis, S.; Henriques, S. T.; Craik, D. J.

J. Am. Chem. Soc. 2016, 138 (17), 5706-5713. DOI: 10.1021/jacs.6b02575.

 

  • Arginine side-chain modification that occurs during copper-catalysed azide-alkyne click reactions resembles an advanced glycation end product.

Conibear, A. C.; Farbiarz, K.; Mayer, R. L.; Matveenko, M.; Kahlig, H.; Becker, C. F.

Org. Biomol. Chem. 2016, 14 (26), 6205-6211. DOI: 10.1039/c6ob00932h.

 

  • Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide.

Kwon, S.; Bosmans, F.; Kaas, Q.; Cheneval, O.; Conibear, A. C.; Rosengren, K. J.; Wang, C. K.; Schroeder, C. I.; Craik, D. J.

Biotechnol. Bioeng. 2016, 113 (10), 2202-2212. DOI: 10.1002/bit.25993.

 

  • Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins.

Akcan, M.; Clark, R. J.; Daly, N. L.; Conibear, A. C.; de Faoite, A.; Heghinian, M. D.; Sahil, T.; Adams, D. J.; Mari, F.; Craik, D. J.

Biopolymers 2015, 104 (6), 682-692. DOI: 10.1002/bip.22699.

 

  • Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis.

Conibear, A. C.; Wang, C. K.; Bi, T.; Rosengren, K. J.; Camarero, J. A.; Craik, D. J.

J. Phys. Chem. B 2014, 118 (49), 14257-14266. DOI: 10.1021/jp507754c.

 

  • The chemistry and biology of theta defensins.

Conibear, A. C.; Craik, D. J.

Angew. Chem. Int. Ed. Engl. 2014, 53 (40), 10612-10623. DOI: 10.1002/anie.201402167.

 

  • The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: A proof-of-concept study using the integrin-binding RGD motif.

Conibear, A. C.; Bochen, A.; Rosengren, K. J.; Stupar, P.; Wang, C.; Kessler, H.; Craik, D. J.

ChemBioChem 2014, 15 (3), 451-459. DOI: 10.1002/cbic.201300568.

 

  • Exploring DOXP-reductoisomerase binding limits using phosphonated N-aryl and N-heteroarylcarboxamides as DXR inhibitors.

Bodill, T.; Conibear, A. C.; Mutorwa, M. K.; Goble, J. L.; Blatch, G. L.; Lobb, K. A.; Klein, R.; Kaye, P. T.

Bioorg. Med. Chem. 2013, 21 (14), 4332-4341. DOI: 10.1016/j.bmc.2013.04.076.

 

  • The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity.

Conibear, A. C.; Rosengren, K. J.; Daly, N. L.; Henriques, S. T.; Craik, D. J.

J. Biol. Chem. 2013, 288 (15), 10830-10840. DOI: 10.1074/jbc.M113.451047.

 

  • Structural characterization of the cyclic cystine ladder motif of theta-defensins.

Conibear, A. C.; Rosengren, K. J.; Harvey, P. J.; Craik, D. J.

Biochemistry 2012, 51 (48), 9718-9726. DOI: 10.1021/bi301363a.

 

  • Quantification of small cyclic disulfide-rich peptides.

Conibear, A. C.; Daly, N. L.; Craik, D. J.

Biopolymers 2012, 98 (6), 518-524. DOI: 10.1002/bip.22121.

 

  • The chemistry of cyclotides.

Craik, D. J.; Conibear, A. C.

J. Org. Chem. 2011, 76 (12), 4805-4817. DOI: 10.1021/jo200520v.

 

  • Chemical Synthesis of Naturally-Occurring Cyclic Mini-Proteins from Plants and Animals.

Conibear, A. C.; Craik, D. J.

Israel J. Chem. 2011, 51 (8-9), 908-916. DOI: 10.1002/ijch.201100067.

 

  • Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors.

Bodill, T.; Conibear, A. C.; Blatch, G. L.; Lobb, K. A.; Kaye, P. T.

Bioorg. Med. Chem. 2011, 19 (3), 1321-1327. DOI: 10.1016/j.bmc.2010.11.062.

 

  • 31P NMR kinetic study of the tandem cleavage of phosphonate esters by bromotrimethylsilane.

Conibear, A. C.; Lobb, K. A.; Kaye, P. T.

Tetrahedron 2010, 66 (43), 8446-8449. DOI: 10.1016/j.tet.2010.08.058.