Publications
Full publication list: https://orcid.org/0000-0002-5482-6225
2024
- Phosphorylation of the HMGN1 nucleosome binding domain decreases helicity and interactions with the acidic patch.
Iebed, D.*, Gökler T.*, van Ingen, H., & Conibear, A. C.
ChemBioChem. 2024, accepted online. DOI: 10.1002/cbic.202400589
- Tyrosine sulfation modulates the binding affinity of chemokine-targeting nanobodies.
Dilly, J. J., Morgan, A. L., Bedding, M. J., Low, J. K. K., Mackay, J. P., Conibear, A. C., Bhusal, R. P., Stone M. J., Franck, C., & Payne, R. J.
ACS Chem. Biol. 2024, 19, 1426-1432. DOI: 10.1021/acschembio.4c00230
- Semisynthesis of segmentally isotope-labeled and site-specifically palmitoylated CD44 cytoplasmic tail.
Vogl, D. P., Mateos, B., Migotti, M., Felkl, M., Conibear, A. C., Konrat, R., & Becker, C. F. W.
Bioorg. Med. Chem. 2024, 100, 117617. DOI: 10.1016/j.bmc.2024.117617
2023
- Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR.
Kuschert, S., Stroet, M., Chin, Y. K.-Y., Conibear, A. C., Jia, X., Lee, T., Bartling, C. R. O., Strømgaard, K., Güntert, P., Rosengren, K. J., Mark, A. E., & Mobli, M.
Magn. Reson. 2023, 4, 57-72. DOI: 10.5194/mr-4-57-2023.
- Reflections on navigating a pandemic: Perspectives from the Chemical Biology Community.
Conibear, A. C. & Hartrampf, N.
ChemBioChem 2023, 24, e202300258. DOI: 10.1002/cbic.202300258
2021
- Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications.
Niederacher, G.; Urwin, D.; Dijkwel, Y.; Tremethick, D. J.; Rosengren, K. J.; Becker, C. F. W.; Conibear, A. C.
RSC Chem. Biol. 2021, 2, 537-550. DOI: 10.1039/d0cb00175a.
- Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding.
Ho, T. N. T.; Lee, H. S.; Swaminathan, S.; Goodwin, L.; Rai, N.; Ushay, B.; Lewis, R. J.; Rosengren, K. J.; Conibear, A. C.
RSC Med. Chem. 2021, 12 (9), 1574-1584. DOI: 10.1039/d1md00182e.
- Segmental and site-specific isotope labelling strategies for structural analysis of posttranslationally modified proteins.
Vogl, D. P.; Conibear, A. C.; Becker, C. F. W.
RSC Chem. Biol. 2021, 2 (5), 1441-1461. DOI: 10.1039/d1cb00045d.
- A conserved β‐bulge glycine residue facilitates folding and increases stability of the mouse α‐defensin cryptdin‐4.
Clark, R. J.; Phan, T. H.; Song, A.; Ouellette, A. J.; Conibear, A. C.; Rosengren, K. J.
Peptide Science 2021, 114 (1), e24250. DOI: 10.1002/pep2.24250.
2020
- Deciphering protein post-translational modifications using chemical biology tools.
Conibear, A. C.
Nat. Rev. Chem. 2020, 4 (12), 674-695. DOI: 10.1038/s41570-020-00223-8.
- Recent Advances in Peptide-Based Approaches for Cancer Treatment.
Conibear, A. C.; Schmid, A.; Kamalov, M.; Becker, C. F. W.; Bello, C.
Curr. Med. Chem. 2020, 27 (8), 1174-1205. DOI: 10.2174/0929867325666171123204851.
- Synthesis and anti-parasitic activity of achiral N-benzylated phosphoramidic acid derivatives.
Adeyemi, C. M.; Conibear, A. C.; Mutorwa, M. K.; Nokalipa, I. C.; Isaacs, M.; Mnkandhla, D.; Hoppe, H. C.; Lobb, K. A.; Klein, R.; Kaye, P. T.
Bioorg. Chem. 2020, 101, 103947. DOI: 10.1016/j.bioorg.2020.103947.
2019
- Random coil shifts of posttranslationally modified amino acids.
Conibear, A. C.; Rosengren, K. J.; Becker, C. F. W.; Kaehlig, H. J.
Biomol. NMR 2019, 73 (10-11), 587-599. DOI: 10.1007/s10858-019-00270-4.
- Multifunctional Scaffolds for Assembling Cancer-Targeting Immune Stimulators Using Chemoselective Ligations.
Conibear, A. C.; Thewes, K.; Groysbeck, N.; Becker, C. F. W.
Front. Chem. 2019, 7, 113. DOI: 10.3389/fchem.2019.00113.
- Tumor-Targeting Immune System Engagers (ISErs) Activate Human Neutrophils after Binding to Cancer Cells.
Potgens, A. J. G.; Conibear, A. C.; Altdorf, C.; Hilzendeger, C.; Becker, C. F. W.
Biochemistry 2019, 58 (22), 2642-2652. DOI: 10.1021/acs.biochem.9b00169.
- Protein Chemistry Looking Ahead: 8(th) Chemical Protein Synthesis Meeting 16-19 June 2019, Berlin, Germany.
Bello, C.; Hartrampf, N.; Walport, L. J.; Conibear, A. C.
Cell Chem. Biol. 2019, 26 (10), 1349-1354. DOI: 10.1016/j.chembiol.2019.09.011.
2018
- Synthetic Cancer-Targeting Innate Immune Stimulators Give Insights into Avidity Effects.
Conibear, A. C.; Potgens, A. J. G.; Thewes, K.; Altdorf, C.; Hilzendeger, C.; Becker, C. F. W.
ChemBioChem 2018, 19 (5), 459-469. DOI: 10.1002/cbic.201700522.
- Native chemical ligation in protein synthesis and semi-synthesis.
Conibear, A. C.; Watson, E. E.; Payne, R. J.; Becker, C. F. W.
Chem. Soc. Rev. 2018, 47 (24), 9046-9068. DOI: 10.1039/c8cs00573g.
- Advancing the Frontiers of Chemical Protein Synthesis-The 7(th) CPS Meeting, Haifa, Israel.
Conibear, A. C.; Muttenthaler, M.
Cell Chem. Biol. 2018, 25 (3), 247-254. DOI: 10.1016/j.chembiol.2018.03.001.
2017
- Multifunctional alphavbeta6 Integrin-Specific Peptide-Pt(IV) Conjugates for Cancer Cell Targeting.
Conibear, A. C.; Hager, S.; Mayr, J.; Klose, M. H. M.; Keppler, B. K.; Kowol, C. R.; Heffeter, P.; Becker, C. F. W.
Bioconjug. Chem. 2017, 28 (9), 2429-2439. DOI: 10.1021/acs.bioconjchem.7b00421.
- A comparative study of synthetic and semisynthetic approaches for ligating the epidermal growth factor to a bivalent scaffold.
Gell, A. L.; Groysbeck, N.; Becker, C. F. W.; Conibear, A. C.
J. Pept. Sci. 2017, 23 (12), 871-879. DOI: 10.1002/psc.3051.
- Synthetic integrin-binding immune stimulators target cancer cells and prevent tumor formation.
Brehs, M.; Potgens, A. J. G.; Steitz, J.; Thewes, K.; Schwarz, J.; Conibear, A. C.; Bartneck, M.; Tacke, F.; Becker, C. F. W.
Sci. Rep. 2017, 7 (1), 17592. DOI: 10.1038/s41598-017-17627-0.
2016 and earlier
- Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization.
Conibear, A. C.; Chaousis, S.; Durek, T.; Rosengren, K. J.; Craik, D. J.; Schroeder, C. I.
Biopolymers 2016, 106 (1), 89-100. DOI: 10.1002/bip.22767.
- Mirror Images of Antimicrobial Peptides Provide Reflections on Their Functions and Amyloidogenic Properties.
Wang, C. K.; King, G. J.; Conibear, A. C.; Ramos, M. C.; Chaousis, S.; Henriques, S. T.; Craik, D. J.
J. Am. Chem. Soc. 2016, 138 (17), 5706-5713. DOI: 10.1021/jacs.6b02575.
- Arginine side-chain modification that occurs during copper-catalysed azide-alkyne click reactions resembles an advanced glycation end product.
Conibear, A. C.; Farbiarz, K.; Mayer, R. L.; Matveenko, M.; Kahlig, H.; Becker, C. F.
Org. Biomol. Chem. 2016, 14 (26), 6205-6211. DOI: 10.1039/c6ob00932h.
- Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide.
Kwon, S.; Bosmans, F.; Kaas, Q.; Cheneval, O.; Conibear, A. C.; Rosengren, K. J.; Wang, C. K.; Schroeder, C. I.; Craik, D. J.
Biotechnol. Bioeng. 2016, 113 (10), 2202-2212. DOI: 10.1002/bit.25993.
- Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins.
Akcan, M.; Clark, R. J.; Daly, N. L.; Conibear, A. C.; de Faoite, A.; Heghinian, M. D.; Sahil, T.; Adams, D. J.; Mari, F.; Craik, D. J.
Biopolymers 2015, 104 (6), 682-692. DOI: 10.1002/bip.22699.
- Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis.
Conibear, A. C.; Wang, C. K.; Bi, T.; Rosengren, K. J.; Camarero, J. A.; Craik, D. J.
J. Phys. Chem. B 2014, 118 (49), 14257-14266. DOI: 10.1021/jp507754c.
- The chemistry and biology of theta defensins.
Conibear, A. C.; Craik, D. J.
Angew. Chem. Int. Ed. Engl. 2014, 53 (40), 10612-10623. DOI: 10.1002/anie.201402167.
- The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: A proof-of-concept study using the integrin-binding RGD motif.
Conibear, A. C.; Bochen, A.; Rosengren, K. J.; Stupar, P.; Wang, C.; Kessler, H.; Craik, D. J.
ChemBioChem 2014, 15 (3), 451-459. DOI: 10.1002/cbic.201300568.
- Exploring DOXP-reductoisomerase binding limits using phosphonated N-aryl and N-heteroarylcarboxamides as DXR inhibitors.
Bodill, T.; Conibear, A. C.; Mutorwa, M. K.; Goble, J. L.; Blatch, G. L.; Lobb, K. A.; Klein, R.; Kaye, P. T.
Bioorg. Med. Chem. 2013, 21 (14), 4332-4341. DOI: 10.1016/j.bmc.2013.04.076.
- The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity.
Conibear, A. C.; Rosengren, K. J.; Daly, N. L.; Henriques, S. T.; Craik, D. J.
J. Biol. Chem. 2013, 288 (15), 10830-10840. DOI: 10.1074/jbc.M113.451047.
- Structural characterization of the cyclic cystine ladder motif of theta-defensins.
Conibear, A. C.; Rosengren, K. J.; Harvey, P. J.; Craik, D. J.
Biochemistry 2012, 51 (48), 9718-9726. DOI: 10.1021/bi301363a.
- Quantification of small cyclic disulfide-rich peptides.
Conibear, A. C.; Daly, N. L.; Craik, D. J.
Biopolymers 2012, 98 (6), 518-524. DOI: 10.1002/bip.22121.
- The chemistry of cyclotides.
Craik, D. J.; Conibear, A. C.
J. Org. Chem. 2011, 76 (12), 4805-4817. DOI: 10.1021/jo200520v.
- Chemical Synthesis of Naturally-Occurring Cyclic Mini-Proteins from Plants and Animals.
Conibear, A. C.; Craik, D. J.
Israel J. Chem. 2011, 51 (8-9), 908-916. DOI: 10.1002/ijch.201100067.
- Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors.
Bodill, T.; Conibear, A. C.; Blatch, G. L.; Lobb, K. A.; Kaye, P. T.
Bioorg. Med. Chem. 2011, 19 (3), 1321-1327. DOI: 10.1016/j.bmc.2010.11.062.
- 31P NMR kinetic study of the tandem cleavage of phosphonate esters by bromotrimethylsilane.
Conibear, A. C.; Lobb, K. A.; Kaye, P. T.
Tetrahedron 2010, 66 (43), 8446-8449. DOI: 10.1016/j.tet.2010.08.058.