Anne Claire Conibear

Assistant Prof., MSc PhD

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+43 1 58801 - 163723

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Dr. Anne C. Conibear


Institute of Applied Synthetic Chemistry, Faculty of Technical Chemistry

TU Wien, Vienna, Austria

Link to Lab Website


Tel: +43 1 58801 163723

Twitter: @AnneConibear

ORCID: 0000-0002-5482-6225; Google Scholar

Research Interests

Chemical Biology

Protein Chemistry

Peptide Synthesis

Posttranslational Modifications

Protein Degradation



My research uses protein and peptide chemistry tools to make unique site-specifically modified proteins to probe the effects of posttranslational modifications in fundamental biological processes such as protein degradation and packaging of genetic material.

My research uses protein and peptide chemistry tools to make unique site-specifically modified proteins to probe the effects of posttranslational modifications in fundamental biological processes such as protein degradation and packaging of genetic material.


Academic Career

2022 –             Assistant Professor (Tenure Track) in Protein Chemistry | Faculty of Technical Chemistry, TU Wien

                         Honorary Research Fellow | School of Biomedical Sciences, The University of Queensland

2019 – 2021     UQ Development Fellow (Senior Research Fellow) | School of Biomedical Sciences, The University of Queensland

2014 – 2018     Interdisciplinary Cancer Research (INDICAR) Postdoctoral Fellow | Institute of Biological Chemistry, University of Vienna

Higher education and academic qualifications

2011 – 2014     PhD (Biomolecular Chemistry), The University of Queensland, Australia

2009 – 2010     MSc. (Chemistry, with distinction), Rhodes University, South Africa

2008                  BSc.(Hons) (Chemistry, with distinction), Rhodes University, South Africa

2005 – 2007     BSc. (Chemistry & Biochemistry, with distinction), Rhodes University, South Africa

Research funding

  • Posttranslational modification of HMGN1 in DNA packaging | Stand Alone Project (2022-2026), Austrian Science Fund (FWF) | PI.
  • Expanding access to modified proteins via a novel semi-synthetic platform | Discovery Project (2022 - 2024), Australian Research Council | Co-PI with Prof. Richard Payne (The University of Sydney).
  • Australian Peptide Display Facility | Large Equipment and Infrastructure (LIEF) Grant (2022), Australian Research Council | with Prof. Richard Payne and Prof. Joel Mackay (The University of Sydney).
  • Decorated venom: Exploring the role of cone snail venom modifications I Early Career Researcher Grant (2020), The University of Queensland | PI.
  • Investigating the role of posttranslational modifications on protein structure and function using selective and segmental isotope labelling | Research Grant (2019 - 2021), Cambridge Isotope Laboratories Inc. | PI.
  • Insights into protein modifications by NMR | UQ Development Fellowship (2019 - 2021), The University of Queensland | PI.
  • Zooming in on protein functional sites with atomic resolution (Structure Zoom) | Life Sciences Project (2018 - 2021), Vienna Science and Technology Fund (WWTF) | Co-PI with Prof. Christian Becker and Prof. Robert Konrat (University of Vienna).
  • Synthetic antibodies for cancer therapy (SAbs) | Interdisciplinary Cancer Research (INDICAR) Postdoctoral Fellowship (2014 – 2018), Mahlke-Obermann Stiftung and European Union Seventh Framework Programme Marie Curie Actions | PI.

Academic prizes and awards

  • Career Track Award from the School of Biomedical Sciences, UQ (2019, 2020, 2021)
  • Dean’s Award for Outstanding Research Higher Degree Theses (2014)
  • University of Queensland ‘Class of 2014 Future Leaders’ award (2014)
  • South African Chemical Society James Moir Medal for Chemistry Honours (2009)

Research student supervision and mentorship

PhD theses

Dina Iebed (started Jan 2023) | TU Wien

Medine Soydan (started Jan 2023) | TU Wien

Oliver Gajsek (started March 2020) | Co-supervision with Prof. Christian Becker (University of Vienna).

Dominik Vogl (started July 2019) | Co-supervision with Prof. Christian Becker (University of Vienna).

Master's theses

Tobias Gökler (started March 2023) | TU Wien

Victoria Adegoke (MPhil, started January 2022) | International Postgraduate Scholarship | Co-supervision with Dr. Johan Rosengren (The University of Queensland).

Oliver Gajsek (MSc, 2018) | University of Vienna.

Anna-Lena Gell (MSc, 2017) | University of Vienna.

Nadja Groysbeck (MSc, 2016) | University of Vienna.

Honours theses and Undergraduate research projects

Fatima Shabbir (2021) | The University of Queensland.

Undergraduate research students, SCIE3220, Summer Research Projects (2019-2021) | The University of Queensland.

‘Wahlbeispiel’ (internship) projects (2015-2018) | University of Vienna.

Teaching experience

  • TU Wien: Total Synthesis Lecture; Natural Products Module; Synthesis Practical; Foundational Chemistry Laboratory; Green Chemistry Laboratory.
  • The University of Queensland: CHEM1090 ‘Introductory Chemistry’; BIOL1040/BIOL1051 ‘Cells to Organisms’; CHEM1221 ‘General, Organic & Biological Chemistry’; BIOT3002 ‘Drug Design & Development’; SCIE3221 ‘Research Skills’; BIOM6191 ‘Biomedical Science Honours’.
  • University of Vienna: Chemical Biology (MSc level, Winter Semester 2016/17 and 2017/18)
  • Internship student supervision (University of Vienna and University of Queensland).
  • Chemistry tutoring (University of Vienna, St. John’s College, Brisbane, and Rhodes University)
  • Rhodes University: Laboratory practical leader and demonstrator

Invited talks, conference presentations and seminars

  • Invited talks at international conferences: 7
  • Selected oral presentations at international conferences: 9
  • Invited seminars at universities/institutes: 7

Selected Publications

Total number of peer-reviewed publications: 34

Full publication list:

* denotes corresponding author

  1. Ho, T. N. T., Lee, H. S., Swaminathan, S., Goodwin, L., Rai, N., Ushay, B., Lewis, R., Rosengren, K. J. & Conibear, A. C.*, Posttranslational modifications of α-conotoxins: Sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. RSC Med. Chem. 2021, accepted online 26.07.2021. DOI:10.1039/D1MD00182E.
  2. Niederacher, N., Urwin, D., Dijkwel, Y., Tremethick, D. J., Rosengren, K. J., Becker, C. F. W. & Conibear, A. C.*, Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications. RSC Chem. Biol. 2021, 2, 537-550. DOI: 10.1039/d0cb00175a.
  3. Conibear, A. C.*, Deciphering protein post-translational modifications using chemical biology tools. Nat. Rev. Chem. 2020, 4, 674-695. DOI:10.1038/s41570-020-00223-8.
  4. Conibear, A. C.*, Rosengren, K. J., Becker, C. F. W. & Kaehlig, H., Random coil shifts of posttranslationally modified amino acids. J. Biomol. NMR 2019, 73, 587-599. DOI: 10.1007/s10858-019-00270-4.
  5. Conibear, A. C., Watson, E. E., Payne, R. J. & Becker, C. F. W. Native chemical ligation in protein synthesis and semi-synthesis. Chem. Soc. Rev. 2018, 47, 9046-9068, DOI:10.1039/c8cs00573g.
  6. Conibear, A. C.*, Potgens, A., Thewes, K., Altdorf, C., Hilzendeger, C. & Becker, C. F. W.* Synthetic cancer-targeting innate immune stimulators give insights into avidity effects, ChemBioChem 2018, 19, 459-469. DOI:10.1002/cbic.201700522.
  7. Conibear, A. C., Hager, S., Mayr, J., Klose, M. H. M., Keppler, B. K., Kowol, C. R., Heffeter, P.& Becker, C. F. W. Multifunctional αvβ6 integrin-specific peptide-Pt(IV) conjugates for cancer cell targeting, Bioconj. Chem. 2017, 28, 2429-2439. DOI: 10.1021/acs.bioconjchem.7b00421.
  8. Wang, C. K., King, G. J., Conibear, A. C., Ramos, M. C., Chaousis, S., Henriques, S. T., and Craik, D. J. Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties, J. Am. Chem. Soc. 2016, 138, 5706-5713. DOI: 10.1021/jacs.6b02575.
  9. Conibear, A. C. and Craik, D. J. The chemistry and biology of theta-defensins, Angew. Chem. Int. Ed. Engl. 2014, 53, 10612-10623. DOI: 10.1002/anie.201402167.
  10. Conibear, A. C., Rosengren, K. J., Daly, N. L., Henriques, S. T., and Craik, D. J. The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity, J. Biol. Chem. 2013, 288, 10830-10840. DOI: 10.1074/jbc.M113.451047.